Endocrine Abstracts

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and cardiometabolic disturbances. This study aims to determine the prevalence of obesity in patients with acromegalyPatients and Methods : We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker University Hospital, Sfa...

Objective: To describe the phenotypic and molecular characteristics of familial thyroid dyshormonogenesis (FTDH) in the Tunisian population.Patients and Methods: A retrospective descriptive study including two related (R and K) with high consanguinity whose members are carriers of FTDH. Biological and genetic screening was proposed for all consenting members.Results: FTDH was identified in 11 patients (8 girls, 3 boys) with a mean ...

Background: The management of differentiated microcarcinomas of the thyroid (DMCT) is controversial, and ranges from simple active surveillance to total thyroidectomy with bilateral lymph node dissection and post operative adjuvant therapy. Our purpose was to determine prognostic factors to guide the surgery of DMCT.Methods: This was a retrospective study conducted from January 2000 to December 2017, involving 122 patients with DMCT who were treated surg...

Introduction: Thyroidectomy is a quite common procedure. Major postoperative complications of total thyroidectomy, including recurrent laryngeal nerve injur and hypocalcemia are not infrequent. The purpose of this study was to evaluate the incidence and risk factors of postoperative complications after total thyroidectomy.Methods: We retrospectively included patients who underwent total thyroidectomy over a period of 6 years. Hypocalcemia was defined as ...

Background: True thymic hyperplasia results from stressful situations such as chemotherapy. It commonly presents as an anterior mediastinal mass; cervical location is exceptional. The aim of this work is to illustrate a case of an incidental ectopic cervical thymic hyperplasia in a patient treated for Hodgkin lymphoma.Case reprt : Here we report a case of a cervical true thymic hyperplasia in a 12-year-old girl who had a Hodgkin lymphoma treated by radio...

Background and aim: Hyperthyroidism status can be complicated by polymorphic neuromuscular manifestations sometimes revealing. In the majority of cases, these disorders regress during the transition to euthyroidism. We report in this work 6 observations illustrating the neuromuscular manifestations seen in hyperthyroidism.Observations: We report two cases of chronic myopathy: a man and a woman aged 47 and 55 years respectively, hospitalized for hyperthyr...

The autoimmune thyroid disease (AITDs) comprises two clinical phenotype, Graves’ disease (GD) and autoimmune hypothyroidism (AIH), which include goitrous [Hashimoto thyroiditis (HT)] and non goitrous forms [Primary idiopathic myxoedema (PIM)]. These disorders are characterized by loss of immunological self tolerance including the presence of a thyroid lymphocytic infiltrate and autoantibodies to thyroglobulin (Tg) and thyroid peroxidase (TPO). Inheritance of AITDs is comp...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder caused by mutations in the MEN1 tumor suppressor gene and is characterized clinically by tumors in two or more endocrine glands, such as the pituitary gland, parathyroid glands or pancreatic islets. We describe an atypical presentation of familial hyperparathyroidism evoking the diagnosis of MEN1 in the first place.Observations: We report a three-member family....

Intoduction: Pitiutary tumor is considered as the first etiology responsable of secondary hypopituitarism. Hypogonadotropic hypogonadism is the most commonly reported lesion.Meterials and methods: It is a retrospective study including 77 cases of prolactinoma. The data collection was done over 17 years, between 2000 and 2017.Results: Gonadotropic deficiency was confirmed in 48 patients (63.6%). A significant negative correlation wa...

Introduction: The non-functional pituitary adenoma (NFPA) is a benign tumor, which has a progressive development but it is a severe tumor by its neuro-ophthalmological and endocrine repercussions.Patients and methods: It is about a descriptive and retrospective study conducted in 35 patients collected in the endocrinology department of Sfax between January 2000 and December 2017. The diagnosis of NFPA was based on the presence of pituitary adenoma on hyp...